A throwing game script is indicated by the Colts being a -4.5-point underdog in this game.This game will be played in a dome—meaning no wind, increased pass volume, increased touchdown potential, and increased passing effectiveness.Opposing teams have averaged 35.3 pass attempts per game against the Bills defense this year: 8th-most in the NFL.As it relates to protecting the passer (and the positive impact it has on all pass attack stats), the offensive line of the Indianapolis Colts grades out as the best in football this year.Alec Pierce's sure-handedness have improved this year, with his Adjusted Catch% jumping from 50.7% to 58.6%.
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