Expert Picks and Betting Line for Brewers vs Cardinals – Sunday September 21st, 2025

Milwaukee Brewers

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St. Louis Cardinals

As the St. Louis Cardinals prepare to face the Milwaukee Brewers on September 21, 2025, they find themselves at the bottom of the National League Central standings with a disappointing record of 75-80. Meanwhile, the Brewers are having a stellar season at 95-60 and are looking to solidify their playoff positioning. In their last matchup, the Cardinals narrowly lost 3-2, while the Brewers emerged victorious by the same score, adding pressure to the struggling Cardinals.

On the mound, St. Louis is set to start Matthew Liberatore, who has had an inconsistent season with a 7-12 record and a 4.30 ERA. While Liberatore’s last outing was promising, where he pitched 6 innings allowing just 2 earned runs and striking out 6, he has been labeled as a below-average pitcher in advanced-stat Power Rankings, ranking 179th out of approximately 350 pitchers. His projections suggest he may pitch around 4.9 innings today, with a tendency to allow 2.8 earned runs and 5.6 hits, which could pose challenges against the Brewers’ powerful lineup.

On the other hand, Milwaukee will counter with Robert Gasser, who, while considered an average pitcher, has been known to deliver solid performances. Gasser’s recent outing on June 1 showed some vulnerabilities, yielding 3 earned runs in 5 innings. However, he projects to allow just 2.3 earned runs today, which bodes well for the Brewers.

Offensively, the Cardinals rank 23rd in MLB, struggling with a mere 28th rank in home runs, while the Brewers boast an impressive 8th rank overall and an excellent 2nd rank in team batting average. With a Game Total of 8.5 runs, the expectations for scoring remain moderate. The projections favor the Brewers, although the Cardinals’ odds reflect the potential for an upset in what promises to be an intriguing matchup.

Milwaukee Brewers Insights

• Milwaukee Brewers – 2H Moneyline
  The Milwaukee Brewers bullpen grades out as the 2nd-worst in Major League Baseball, via the leading projection system (THE BAT).
  Explain: Most bettors only consider the starting pitcher, but a weak bullpen sneakily creates an easier matchup for the opposing offense and boosts a game’s runs.

St. Louis Cardinals Insights

• St. Louis Cardinals – Moneyline (+115)
  Among all the teams playing today, the 3rd-strongest infield defense is that of the St. Louis Cardinals.
  Explain: Defense is an integral part of preventing hits and runs.

Betting Trends

• St. Louis Cardinals – Over/Under 3.5 Team Total (-130/+100)
  The St. Louis Cardinals have hit the Team Total Under in 44 of their last 75 games (+8.75 Units / 10% ROI)
• Milwaukee Brewers – Moneyline (-135)
  The Milwaukee Brewers have hit the Moneyline in 70 of their last 103 games (+31.00 Units / 22% ROI)