Find Betting Odds and Bets for Padres vs White Sox – September 20th, 2025

San Diego Padres

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Chicago White Sox

As the Chicago White Sox host the San Diego Padres at Guaranteed Rate Field on September 20, 2025, both teams are looking to build momentum in this Interleague matchup. The White Sox are struggling this season with a record of 58-96, while the Padres sit comfortably above .500 at 83-71. The stakes are relatively low for the White Sox, who have been eliminated from division contention, yet they managed to pull off a narrow 4-3 victory over the Padres in their last meeting.

On the mound, the White Sox will send out Yoendrys Gomez, who has had a mixed season. Despite being ranked as the 205th best starting pitcher in MLB, Gomez has shown flashes of potential, including a solid outing in his last start where he pitched 5 innings with only 2 earned runs. However, his projections indicate he may struggle today, as he is expected to pitch just 4.7 innings while allowing 2.7 earned runs, 4.9 hits, and 1.7 walks on average.

In contrast, the Padres will counter with Yu Darvish, who has had an average season but is projected to perform better in this outing. Darvish’s xFIP of 4.12 suggests he has been somewhat unlucky, and his projections for today show he is expected to pitch 5.0 innings with 2.2 earned runs allowed. With the Padres’ offense ranking 19th overall but excelling in batting average at 8th, they have the edge against a White Sox lineup that ranks 28th in MLB.

With the White Sox’s offense struggling and the Padres having a strong bullpen ranked 1st, the odds are stacked against Chicago. The current moneyline reflects this, with the White Sox as underdogs at +155. Given the projections and recent performance, the Padres look poised to capitalize on their offensive advantages and secure a win.

San Diego Padres Insights

• Yu Darvish – Over/Under 5.5 Strikeouts (+115/-150)
  Yu Darvish’s cut-fastball percentage has increased by 8.4% from last season to this one (4.8% to 13.2%) .
  Explain: Because cutters are one of the most effective pitches to use, a pitcher who alters his pitch mix to use more of them will often see more success as a result.
• Ryan O’Hearn – Over/Under 0.5 Hits (-165/+125)
  Ryan O’Hearn has primarily hit in the top-half of the lineup this season (86% of the time), but he is projected to bat 7th in the batting order in this game.
  Explain: The lower in the order a player bats, the fewer plate appearances he will get and the fewer opportunities he will get to hit the Over for every market. A player who hits lower in the order than he normally does may provide extra value opportunity since the market may be based on him hitting higher.
• San Diego Padres – 2H Moneyline
  According to the leading projection system (THE BAT), the San Diego Padres’ bullpen projects as the best out of all teams in Major League Baseball.
  Explain: Most bettors only consider the starting pitcher, but a strong bullpen sneakily creates a tougher matchup for the opposing offense and suppresses a game’s runs.

Chicago White Sox Insights

• Yoendrys Gomez – Over/Under 3.5 Strikeouts (-160/+125)
  Out of all starters, Yoendrys Gomez’s fastball spin rate of 2467 rpm ranks in the 88th percentile this year.
  Explain: Spin rate is a key component to fastball success in generating strikeouts and preventing runs.
• Colson Montgomery – Over/Under 0.5 Total Bases (-155/+120)
  Colson Montgomery has been cold lately, with his seasonal exit velocity of 88.6-mph dropping to 81.7-mph in the past 7 days.
  Explain: Hitting the ball hard increases the chances of either a home run or the ball landing in fair territory for a hit before a fielder can get to it.
• Colson Montgomery – Over/Under 0.5 Total Bases (-155/+120)
  Colson Montgomery pulls many of his flyballs (36.3% — 92nd percentile) and sets up very well considering he’ll be hitting them towards the league’s 9th-shallowest RF fences in today’s matchup.
  Explain: This player’s skill set matches up particularly well with the park he’s in today, which may lead to better-than-usual performance.

Betting Trends

• Chicago White Sox – Run Line +1.5 (-110)
  The Chicago White Sox have hit the Run Line in 65 of their last 106 games (+13.85 Units / 10% ROI)
• San Diego Padres – Over/Under 2.5 1st Five Innings (F5) Team Total (+100/-130)
  The San Diego Padres have hit the 1st Five Innings (F5) Team Total Under in 69 of their last 119 games (+13.15 Units / 9% ROI)
• Jackson Merrill – Over/Under 0.5 Hits (-245/+185)
  Jackson Merrill has hit the Hits Under in 16 of his last 25 away games (+8.25 Units / 20% ROI)