Check Out Comprehensive Player Prop Odds for Reds vs D-Backs – Friday, August 22, 2025

Cincinnati Reds

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Arizona Diamondbacks

On August 22, 2025, the Arizona Diamondbacks will host the Cincinnati Reds at Chase Field in what promises to be an exciting matchup. The Diamondbacks, despite a below-average season with a record of 62-66, boast the 4th best offense in MLB, an impressive ranking given their struggles. Meanwhile, the Reds sit at 67-61, enjoying an above-average season.

In their last outing, Ryne Nelson is set to take the mound for the Diamondbacks. Nelson has had a solid season, with a Win/Loss record of 6-3 and a respectable ERA of 3.58. He projects to pitch around 5.6 innings today but may surrender 2.6 earned runs on average. However, his ability to strike out batters has been below average this season. Facing him will be Zack Littell, who has a 9-8 record and a slightly better ERA of 3.52. Littell has pitched 25 games this year and is known for his low walk rate, but his 4.22 xFIP suggests he could be in for a rough outing against the patient Diamondbacks offense, which ranks 6th in MLB for drawing walks.

This game marks the first in the series between these two teams, and the Diamondbacks will be looking to leverage their powerful offense, which ranks 5th in home runs this season. The oddsmakers have made the Diamondbacks the betting favorite with a moneyline of -140 and an implied team total of 4.78 runs, reflecting confidence in their ability to capitalize on their offensive prowess against a Reds team that ranks 22nd in home runs.

With both teams fighting for better positioning as the season progresses, today’s matchup could have significant implications. The Diamondbacks, despite their up-and-down year, look to exploit Littell’s inconsistencies and add a win to their record.

Cincinnati Reds Insights

• Zack Littell – Over/Under 3.5 Strikeouts (-125/-105)
  Zack Littell has utilized his slider 5.9% less often this year (34%) than he did last season (39.9%).
  Explain: Because sliders are one of the most effective pitches to use, a pitcher who alters his pitch mix to use them less often may see less success as a result, particularly if he uses his fastball more instead.
• Jose Trevino – Over/Under 1.5 Total Bases (+140/-180)
  Jose Trevino has been cold recently, with his seasonal exit velocity of 87.8-mph dropping to 83.7-mph over the past two weeks.
  Explain: Hitting the ball hard increases the chances of either a home run or the ball landing in fair territory for a hit before a fielder can get to it.
• Zack Littell – Over/Under 3.5 Strikeouts (-125/-105)
  According to the leading projection system (THE BAT), Jose Trevino (the Reds’s expected catcher in today’s game) projects as an elite pitch framer.
  Explain: Pitch framing is a catcher’s ability to make a ball look like a strike to the umpire, “stealing” strikes for his pitcher. This leads to more positive outcomes (like strikeouts) and fewer negative ones (like walks or earned runs).

Arizona Diamondbacks Insights

• Arizona Diamondbacks – Moneyline (-135)
  The Arizona Diamondbacks outfield defense grades out as the 2nd-strongest among every team playing today.
  Explain: Defense is an integral part of preventing hits and runs.
• Geraldo Perdomo – Over/Under 1.5 Total Bases (+140/-180)
  Despite posting a .364 wOBA this year, the leading projection system (THE BAT X) believes Geraldo Perdomo has had some very good luck given the .052 difference between that mark and his estimated true talent wOBA of .312.
  Explain: Players that are overperforming should be expected to play worse going forward, which can create value on prop Unders if the lines are too heavily weighing the lucky, to-date overperformance.
• Arizona Diamondbacks – 2H Moneyline
  The Arizona Diamondbacks bullpen ranks as the 3rd-worst in baseball, via the leading projection system (THE BAT).
  Explain: Most bettors only consider the starting pitcher, but a weak bullpen sneakily creates an easier matchup for the opposing offense and boosts a game’s runs.

Betting Trends

• Arizona Diamondbacks – 1st Five Innings (F5) Moneyline (-145)
  The Arizona Diamondbacks have hit the 1st Five Innings (F5) Moneyline in 55 of their last 104 games (+11.80 Units / 8% ROI)
• Over/Under 9.0 Game Total (-110/-110)
  The Cincinnati Reds have hit the Game Total Under in 62 of their last 100 games (+25.90 Units / 23% ROI)
• Jose Trevino – Over/Under 0.5 Hits (-195/+150)
  Jose Trevino has hit the Hits Under in 11 of his last 20 games (+6.45 Units / 32% ROI)